TIMEROSAL CONTIDO EM VACINAS E TRANSTORNOS DO ESPECTRO AUTISTA: REVISÃO DE LITERATURA
DOI:
https://doi.org/10.36925/sanare.v17i1.1227Resumo
O transtorno do espectro autista (TEA), antes considerado um distúrbio raro, passou a ter prevalência maior do que o câncer infantil, o diabetes e a síndrome de Down. Nos últimos anos houve crescimento exponencial do número de pesquisas sobre fatores ambientais associados ao TEA, dentre os quais se destacam os estudos epidemiológicos de associação entre TEA e timerosal contido em vacinas (TCV). O objetivo deste estudo foi analisar o progresso desses estudos e verificar se há consenso entre os pesquisadores. As bases MedLine e Scopus e a Biblioteca Virtual em Saúde (BVS) foram consultadas para identificar artigos publicados entre 2000 e 2017, adotando como termos de busca (em língua inglesa): “thimerosal”; “thiomersal”; “ethilmercury”; “autism spectrum disorder”; e “autism”. Dezesseis artigos foram selecionados por meio da leitura de títulos e textos. Observou-se que não houve consenso entre os pesquisadores dos Estados Unidos da América (EUA) sobre a associação entre timerosal e TEA, entretanto, todos os autores dos demais países concluíram não haver essa associação.
Referências
Paula CS, Ribeiro SH, Fombonne E, Mercadante MT. Brief report: prevalence of pervasive developmental disorder in Não há consenso entre os pesquisadores sobre a associação entre a exposição ao timerosal e TEA. 100 - SANARE, Sobral - v.17, n.01,p.93-101, Jan./Jun. - 2018 Brazil – a pilot study. J Autism Dev Disord. 2011;41(12):1738- 42.
American Psychiatry Association. DSM-V-TR: manual diagnóstico e estatístico de transtornos mentais. 5. ed. Washington (DC): APA; 2013.
Alsagob M, Colak D, Kaya N. Genetics of autism spectrum disorder: an update on copy number variations leading to autism in the next generation sequencing era. Discov Medicin. 2015. 19:367-379.
Lee YJ, Hwang IC. Relationship between serum ferritin level and blood mercury concentration using data from the Korean National Health and Nutrition Examination Survey (2010-2012). Environ Res. 2014;135:271-5.
Landrigan PJ, Lambertini L, Birnbaum LS. A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ Health Perspect. 2012;120(7):2002-4.
Lyall K, Schmidt RJ, Hertz-Picciotto I. Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int J Epidemiol. 2014;43(2):443-64.
Harari R, Harari F, Gerhardsson L, Lundh T, Skerfving S, Strömberg U, et al. Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador. Toxicol Lett. 2012;213(1):75-82.
Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. A two-phase study evaluating the relationship between thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States. Translational Neurodegeneration. 2013;2(1):25.
Pichichero ME, Gentile A, Giglio N, Umido V, Clarkson T, Cernichiari E, et al. Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines. Pediatrics. 2008;121(2):e208-14.
Yau VM, Green PG, Alaimo CP, Yoshida CK, Lutsky M, Windham GC, et al. Prenatal and neonatal peripheral blood mercury levels and autism spectrum disorders. Environ Res. 2014;133:294-303.
Geier DA, Kern JK, Homme KG, Geier MR. Abnormal brain connectivity spectrum disorders following thimerosal administration. Dose-Response. 2017;15(1): 155932581769084.
Geier DA, Kern JK, Geier MR. Increased risk for an atypical autism diagnosis following thimerosal-containing vaccine exposure in the United States: a prospective longitudinal case-control study in the Vaccine Safety Datalink. J Trace Elem Med Biol. 2017;42:18-24.
Geier DA, Geier MR. An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States. J Toxicol Environ Health. 2006;69(15):1481-95.
Price CS, Thompson WW, Goodson B, Weintraub ES, Croen LA, Hinrichsen VL, et al. Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism. pediatrics. 2010;126(4):656-64.
Uno Y, Uchiyama T, Kurosawa M, Aleksic B, Ozaki N. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. Vaccine. 2015;33(21):2511-6.
Geier DA, Kern JK, Geier MR. A two-phase case-control study of autism risk among children born from the late 1990s through the early 2000s in the United States. Med Sci Monit. 2016;22:5196-202.
Majewska MD, Urbanowicz E, Rok-Bujko P, Namysłowska I, Mierzejewski P. Age-dependent lower or higher levels of hair mercury in autistic children than in healthy controls. Acta Neurobiol Exp. 2010;70(2):196-208.
Gallagher CM, Goodman MS. Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002. J Toxicol Environ Health. 2010;73(24):1665-77.
Geier M, Geier D. thimerosal in childhood vaccines, neurodevelopment disorders, and heart disease in the United States. Journal of the American Physicians and Surgeons. 2003;8(1):6-11.
Geier DA, Geier MR. Neurodevelopmental disorders following thimerosal-containing childhooh immunizations: a follow-up analysis. Int J Toxicol. 2004;23:369-76.
Geier DA, Geier MR. A two-phased population epidemiological study of the safety of thimerosalcontaining vaccines: a follow-up analysis. Med Sci Monit. 2005;11(4):CR160-70.
Geier MR, Geier DA. Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. Exp Biol Med. 2003;228(6):660-4.
Fombonne E, Zakarian R, Bennett A, Meng L, McLeanHeywood D. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics. 2006;118(1):e139-50.
Andrews N, Miller E, Grant A, Stowe J, Osborne V, Taylor B. thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United Kingdom does not support a causal association. Pediatrics. 2004;114(3):584-91.
Verstraeten T, Davis RL, DeStefano F, Lieu TA, Rhodes PH, Black SB, et al. Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases. Pediatrics. 2003;112(5):1039-48. SANARE, Sobral - v.17, n.01,p.93-101, Jan./Jun. - 2018 – 101
Hviid A, Stellfeld M, Wohlfahrt J, Melbye M. Association between thimerosal-containing vaccine and autism. JAMA. 2003;290(13):1763-6.
Geier DA, Geier MR. A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism. Med Sci Monit. 2004;10(3):PI33-9.
Geier DA, Geier MR. A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: a follow-up analysis. Med Sci Monit. 2005;11(4):CR160-70.
Vidal CP, Souza MM, Siniak DS. A importância da educação continuada com os agentes comunitários de saúde: relato de experiência. Sanare (Sobral, Online) [serial on the internet]. 2017 [cited 2018 May 18];16(1):130-5. Available from: https://sanare.emnuvens.com.br/sanare/article/ viewFile/1104/615
Rosemiro F, Ximenes G. Necessidades de qualificação, dificuldades e facilidades dos técnicos de enfermagem na Estratégia Saúde da Família. Sanare (Sobral, Online) [serial on the internet]. 2016 [cited 2018 May 18];15(1):47-54. Available from: file:///D:/927-2057-1-SM.pdf
